Advances in the treatment of neurodegenerative diseases (NDs) are nominal. Currently available therapies are merely symptomatic treatments that cannot prevent the development of the disease. Several herbs have been found very useful for managing neurological diseases. There are immense possibilities to discover a more successful line of ND treatment. Phytochemicals from medicinal plants may play a vital role in maintaining the chemical balance of the brain by affecting the capacity of receptors for the major inhibitory neurotransmitters. A few plants have already gained popularity for the potential treatment of NDs. This volume highlights the therapeutic role of medicinal plants and their scientific validation for improving neuronal health. It presents 15 chapters that cover the herbal treatment of NDs, including Parkinson’s disease and Alzheimer’s disease. The contents cover a range of pharmaceutical agents like sirtuins, berberine, rosmarinic acid and resveratrol. The book serves as a reference for pharmacology and herbal medicine scholars as well as healthcare workers interested in information about alternative and complementary therapies for neurological disorders.
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FOREWORD
Traditional therapies, which are indigenous to India, are believed to be the world’s oldest comprehensive healthcare system, and are now one of the most recognized and widely practiced disciplines of alternative medicine in the world. Medicinal herbs have been in use for treating diseases since ancient times in India. Medicinal herbs generally provide relief without any adverse effects, even after prolonged administration.
Since the last decade, the therapeutic potentials of natural compounds in age-associated neurodegenerative disorders have received major attention. Within the last few years, a search for novel pharmacotherapy from medicinal plants for neurodegenerative disorders has progressed significantly.
The content of the book focuses on natural agents and medicinal herbs that have shown a promising role in reversing neurodegenerative disease’s pathology. The book provides comprehensive information concerning the phytological applications of various medicinal herbs to provide sufficient baseline information that could be used in drug discovery, thereby providing new therapeutics for neurodegenerative diseases. The editors are acknowledged for synchronizing with global authorities on the subject to underline the anti-neurodegenerative effects of medicinal herbs with the potential to benefit mankind.
Prof. Ishan K. Patro
Schools of Studies in Zoology and Neuroscience Jiwaji University
Gwalior, India
PREFACE
Neurodegenerative diseases (NDs) are characterized by progressive neuronal loss (structurally and/or functionally) in different regions of the brain. NDs represent one of the most important public health concerns, as they are the growing cause of death around the world, especially among the elderly. Aging has led to an increase in NDs, such as Alzheimer’s disease, dementia, cerebrovascular impairment, seizure disorders, head injury, and Parkinson’s disease, which are becoming critical due to their irreversibility, lack of effective medication, and the resulting social and financial burdens. Indeed, despite the noteworthy achievements in our understanding of NDs, there has been little achievement in formulating suitable therapies.
Currently, the available treatments for NDs seem to be ineffective, as they only work to ease the symptoms but cannot prevent the disease’s progression. The use of medicinal herbs is emerging as an alternative or integrative therapeutic against NDs because of the preconception that medicinal herbs are consequently safe. Phytochemicals from medicinal plants assume an indispensable job in keeping up the chemical balance of the brain by affecting the capacity of receptors for the major inhibitory neurotransmitters. In a conventional act of medication, a few plants have been accounted for to treat NDs.
This book highlights various homegrown medications and their scientific validation to maintain neuronal wellbeing, utilized in Ayurveda practices and Chinese medication. This book summarizes different phytochemicals from various medicinal herbs that are used as promising therapeutic agents for NDs due to their anti-inflammatory and anti-oxidative as well as anticholinesterase activities. Even though the affinity of receptors or carriers for polyphenols or different phytochemicals of the homegrown arrangements in cerebrum tissues remains to be found out, numerous candidates show up as a potential and promising class of therapeutics for the treatment of ailments with a multifactorial etiology.
Adopting the ethnomedicinal approach, this book addresses the intersection between recent therapeutics for NDs and personalized medicine that will allow a broader range of interventions, including evidence-based natural products.
Surya Pratap Singh
Department of Biochemistry, Institute of Science Banaras Hindu University
Varanasi-221005, India
Hareram Birla
Department of Biochemistry, Institute of Science
Banaras Hindu University
Varanasi-221005, India &
Chetan Keswani
Department of Biochemistry, Institute of Science Banaras Hindu University
Varanasi-221005, India
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