Williams Manual of Hematology 10th edition 2022

• Initial Clinical Evaluation
• Disorders of Red Cells
• Disorders of Granulocytes
• Disorders of Monocytes and Macrophages
• Principles of Therapy for Neoplastic Hematological Disorders
• The Clonal Myeloid Disorders
• The Polyclonal Lymphoid Diseases
• The Clonal Lymphoid and Plasma Cell Diseases
• Disorders of Platelet and Hemostasis
• Disorders of Coagulation Proteins
• Thrombosis and Antithrombotic Therapy
• Transfusion and Hemapheresis

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PREFACE

The 10th edition of Williams Manual of Hematology follows soon after the publication of the new 10th edition of the Williams Hematology textbook, as has been the custom for the last seven editions. The Manual provides a condensation of the essential elements of 95 of the 140 chapters of the textbook, chapters that are focused on describing hematologic diseases or broadly applicable therapeutic approaches, such as hematopoietic stem cell transplantation, the pharmacology and toxicity of antineoplastic drugs, and the application of genetically engineered chimeric antigen receptor T lymphocytes. The Manual provides the clinician with a comprehensive precis of the critical elements of diagnosis and management that is easily accessible and important to the care of patients. It is keyed to the Williams Hematology textbook, allowing the physician to move to its more comprehensive coverage as time and interest permit. We urge all readers to avail themselves of the richness of the full coverage provided in the Williams Hematology 10th edition textbook.

Hematology is a discipline for which the impact of advances in genetics, immunology, molecular biology, biotechnology, biomedical informatics, diagnostic imaging, and cytometry and the application of these disciplines to experimental therapeutics have led to an astounding array of pharmaceutical agents, including monoclonal antibodies, advancing our ability to treat successfully and, with increasing frequency, to cure hematologic diseases. Perhaps the most dramatic of these accomplishments is the advance in the treatment of chronic myelogenous leukemia (CML). At the time of the publication of the 1st edition of Hematology in 1972 (to become Williams Hematology with the 5th edition), the 5-year survival of patients with CMLwas approximately 20%. Today, study of patients consistently taking a tyrosine kinase inhibitor has found that they have a 90% 5-year survival. Analysis has shown that the life expectancy of patients with CMLis within 3 years of the general population in all age categories. Moreover, some patients may be cured, allowing them to stop the drug. This dramatic and profound achievement and other parallel advances in the treatment of the leukemias, lymphomas, myeloma, and the many nonmalignant, but consequential and often life-impairing or life-threatening, diseases of blood cells and coagulation proteins is a testament to the advances flowing from the investment in biomedical research.

This increase in knowledge is reflected in the 10th edition of Williams Hematology being 1024 pages longer than the 1st edition (despite artful editing!); hence, the raison d’être for the Manual as an essential guide for the clinician. The editors of the Manual have endeavored to bring to the reader information, focused on pathogenesis, diagnosis, and management, in an organized and easy-to-use way, to assist the clinician in the examining room, at the bedside, or when using telemedicine. The Manual has been an important resource for clinicians preparing for certification examinations in hematology or other disciplines requiring a knowledge of hematology because the information for patient diagnosis and management is provided in a comprehensive document of manageable size and format and packed with essential information.

We acknowledge the authors of the chapters in the 10th edition of Williams Hematology, who provided the basis for the exposition of pathogenesis, diagnosis, and management in each chapter. We have translated and condensed their current and state-of-the-art information for the users of the Manual.We welcome David Linch, University College London, to the editorial board of the Williams Manual (and textbook), thereby broadening its international perspective and reach. Its international import is attested to by its having been translated into Chinese, Greek, Japanese, Portuguese, Russian, Spanish, and Turkish in one recent edition or another.

We gratefully acknowledge Harriet Lebowitz for editorial development of the manuscript, the administrative support of Jason Malley, and our production manager Richard Ruzycka, each at McGrawHill Education; the valuable assistance of Susan M. Daley in Rochester who provided administrative assistance in the preparation of the manuscript and the management of chapter flow; and Warishree Pant of KnowledgeWorks Global Ltd. for the final composition of the book.

Marshall A. Lichtman, Rochester, New York Kenneth Kaushansky, Stony Brook, New York Josef T. Prchal, Salt Lake City, Utah
Marcel M. Levi, Amsterdam, The Netherlands Linda J. Burns, Milwaukee, Wisconsin
David C. Linch, London, United Kingdom