Infection with Human Papilloma Virus (HPV) and risk of subsites within the oral cancer
Original price was: $24.59.$2.99Current price is: $2.99.
- Title: Infection with Human Papilloma Virus (HPV) and risk of subsites within the oral cancer
- Author: Luca Giraldi a, Giulia Collatuzzo b, Dana Hashim c,d, Silvia Franceschi e, Rolando Herrero f,Chu Chen g, Stephen M. Schwartz g
, Elaine Smith h, Karl Kelsey i, Michael McClean j,Maura Gillison k, Stefania Boccia a, Mia Hashibe l, Yuan-Chin Amy Lee l, Paolo Boffetta b,m,* - Publication: Cancer Epidemiology
- Publisher: Elsevier Inc
- Year: 2021
- Language: English
- Pages: 5
- Format: PDF
- File size: 418 KB
- DOI: 10.1016/j.canep.2021.102020
- CBID: CBR341
Highlights
- •
HPV16 infection may increase the risk of developing cancer within all sites of the oral cavity.
- •
The relationship between HPV16 infection within sites of the oral cavity changes slightly.
- •
Very low prevalence of HPV18 in oral cavity cancer subsites.
Abstract
Background
The aim of this study was to investigate the relationship between high-risk genotypes of Human Papilloma Virus (HPV) and cancer of different subsites of the oral cavity.
Material and methods
A pooled analysis of five studies included on the International Head and Neck Cancer Epidemiology (INHANCE) Consortium was conducted. HPV 16 and HPV 18 were considered. Adjusted odds ratios (ORs) and corresponding 95 % confidence intervals (CIs) for HPV and each oral cavity subsites were simultaneously estimated using multinomial logistic regression models.
Results
The analysis included 1157 cases and 3272 controls. This study showed a slightly higher prevalence of HPV infection among oral cancer cases than controls. In particular, an increased risk of other and not otherwise specified (NOS) sites within the oral cavity, oral tongue, palate and floor of mouth cancer was observed for overall HPV16 positivity (OR = 1.66, 95 % CI: 1.01−2.72; OR = 1.97, 95 % CI: 1.36−2.85; OR = 2.48, 95 % CI: 1.50−4.11; OR = 2.71, 95 % CI: 1.06−6.95, respectively). In particular, HPV16E7 was related to cancer of floor of mouth, oral cavity NOS and palate (OR = 2.71, 95 % CI: 1.06−6.95; OR = 3.32, 95 % CI:1.53−7.19; OR = 3.34, 95 % CI:1.38−8.06). Results were inconsistent for HPV18 due to low prevalence of infection.
Conclusion
Our study suggests that HPV16 infection may increase the risk of developing floor of mouth, gum, tongue, and palate cancers.
Clinical relevance
Subjects with HPV infection have a higher risk of cancer from all sites of the oral cavity.
1
Introduction
Cancer of the oral cavity is the 16th most common cancer worldwide, with an estimated number of 377,000 new cases diagnosed in 2020 worldwide [ ]. Although the overall incidence of this malignancy is slightly decreasing with an annual percentage change around -1%, in the last decade an increase in the percentage of young patients was observed [ ].
The main risk factors for oral cancers are tobacco smoking and alcohol consumption, while there are suggestions that also diet and oral hygiene can play a role [ ]. Infection with Human Papillomavirus (HPV) is a recognized risk factor for cancer of the oropharynx, an organ anatomically contiguous to the oral cavity [ ]. The relationship between HPV infection and oral cavity cancer has also been studied, with inconclusive results [ ]. A case-control study conducted in Sweden reported a positive association with HPV16 infection [ ], similarly, a case-control study conducted in Canada in 2008 reported a non-significant association [ ]. A meta-analysis including more than 2500 patients with cancer of oral cavity reported an overall prevalence of HPV of 23.5 %, with predominance of HPV16 (16 % of the cases) and HPV18 (8%) [ ]. In 2011, the IARC concluded that there was sufficient evidence for a causal role of HPV16 in oral cavity cancer, while a role of HPV18 was considered possible [ ]. Moreover, in 2013 the ARCAGE study reported that 32 % of 359 oral cavity cancer cases were HPV16 positive [ ].
The oral cavity includes different subsites, including floor of mouth, gum, buccal mucosa, oral tongue and palate. These sites may have different opportunity of exposure to HPV infection due to their different location, and it would be important to examine the empirical evidence of a role of HPV infection on specific subsites of the oral cavity, which is mainly based on case-control studies [ , ]. To further explore this issue we decided to investigate the relationship between HPV infection and the risk of specific subsites within the oral cavity cancer through a pooled analysis of case-control studies included in the International Head and Neck Cancer Epidemiology (INHANCE) Consortium [ ].
Be the first to review “Infection with Human Papilloma Virus (HPV) and risk of subsites within the oral cancer”
Related products
Reviews
There are no reviews yet.