Now in a fully revised thirteenth edition, Andrews’ Diseases of the Skin remains your single-volume, must-have resource for core information in dermatology. From residency through clinical practice, this award-winning title ensures that you stay up to date with new tools and strategies for diagnosis and treatment, new entities and newly recognized diseases, and current uses for tried-and-true and newer medications. It’s the reference you’ll turn to again and again when faced with a clinical conundrum or therapeutically challenging skin disease.

Table of contents

• Cover image
• Title Page
• Table of Contents
• Copyright
• Video Contents
• Preface and Acknowledgments to the Thirteenth Edition
• Dedication
• The Authors
• 1 Skin
• Epidermis and Adnexa
• Dermoepidermal Junction
• Epidermal Appendages (Adnexa)
• Dermis
• Subcutaneous Tissue (Fat)
• 2 Cutaneous Signs and Diagnosis
• Cutaneous Signs
• General Diagnosis
• 3 Dermatoses Resulting From Physical Factors
• Heat Injuries
• Cold Injuries
• Actinic Injury
• Photosensitivity
• Radiodermatitis
• Mechanical Injuries
• Foreign Body Reactions
• 4 Pruritus and Neurocutaneous Dermatoses
• Pruritus
• Pruritic Dermatoses
• Cutaneous Dysesthesia Syndromes
• 5 Eczema, Atopic Dermatitis, and Noninfectious Immunodeficiency Disorders
• Eczema
• Atopic Dermatitis (Atopic Eczema)
• Hormone-Induced Dermatoses
• Immunodeficiency Syndromes
• 6 Contact Dermatitis and Drug Eruptions
• Contact Dermatitis
• Drug Reactions
• 7 Erythema and Urticaria
• Flushing
• Erythemas
• Eosinophilic Cellulitis (Wells Syndrome)
• Reactive Neutrophilic Dermatoses
• Autoinflammatory Syndromes
• Urticaria (Hives)
• 8 Connective Tissue Diseases
• Lupus Erythematosus
• Dermatomyositis
• Scleroderma
• Eosinophilic Fasciitis
• Mixed Connective Tissue Disease
• Nephrogenic Systemic Fibrosis
• Sjögren Syndrome (Sicca Syndrome)
• Reactive Palisading Granulomatous Dermatitis
• Relapsing Polychondritis
• 9 Mucinoses
• Lichen Myxedematosus
• Scleredema
• Reticular Erythematous Mucinosis (REM Syndrome, Plaquelike Cutaneous Mucinosis)
• Follicular Mucinosis (Alopecia Mucinosa)
• Cutaneous Focal Mucinosis
• Myxoid Cysts
• Chapter References
• 10 Seborrheic Dermatitis, Psoriasis, Recalcitrant Palmoplantar Eruptions, Pustular Dermatitis, and Erythroderma
• Seborrheic Dermatitis
• Psoriasis
• Reactive Arthritis With Conjunctivitis/Urethritis/Diarrhea (Reiter Syndrome)
• Subcorneal Pustular Dermatosis (Sneddon-Wilkinson Disease)
• Eosinophilic Pustular Folliculitis
• Recalcitrant Palmoplantar Eruptions
• 11 Pityriasis Rosea, Pityriasis Rubra Pilaris, and Other Papulosquamous and Hyperkeratotic Diseases
• Pityriasis Rosea
• Pityriasis Rubra Pilaris
• Small Plaque Parapsoriasis
• Confluent and Reticulated Papillomatosis (Gougerot and Carteaud)
• Palmoplantar Keratoderma
• Focal Palmoplantar Keratodermas
• Diffuse Palmoplantar Keratodermas
• Other Palmoplantar Keratodermas
• Other Palmoplantar Dermatoses
• Exfoliative Dermatitis (Erythroderma)
• 12 Lichen Planus and Related Conditions
• Lichen Planus
• Keratosis Lichenoides Chronica
• Lichen Nitidus
• Lichen Striatus
• Lichen Sclerosus (Lichen Sclerosus Et Atrophicus)
• 13 Acne
• Acne Vulgaris
• Acne Conglobata
• Acne Fulminans
• SAPHO and Related Syndromes
• Other Acne Variants
• Acneiform Eruptions
• Gram-Negative Folliculitis
• Acne Keloidalis
• Hidradenitis Suppurativa
• Dissecting Cellulitis of the Scalp
• Acne Miliaris Necrotica (Acne Varioliformis)
• Rosacea
• Pyoderma Faciale (Rosacea Fulminans)
• Perioral Dermatitis
• Granulomatous Facial Dermatitis
• 14 Bacterial Infections
• Infections Caused by Gram-Positive Organisms
• Infections Caused by Gram-Negative Organisms
• Rickettsial Diseases
• 15 Diseases Resulting From Fungi and Yeasts
• Superficial and Deep Mycoses
• The Superficial Mycoses
• The Deep Mycoses
• Disease Caused by Algae (Protothecosis)
• 16 Mycobacterial Diseases
• Tuberculosis
• Nontuberculous Mycobacteriosis
• 17 Hansen Disease
• Epidemiology
• The Infectious Agent
• Diagnosis
• Classification
• Nerve Involvement
• Ocular Involvement
• Mucous Membrane Involvement
• Visceral Involvement
• Special Clinical Considerations and Hansen Disease
• Immunopathogenesis
• Histopathology
• Reactional States
• Treatment
• Management of Reactions
• Prevention
• 18 Syphilis, Yaws, Bejel, and Pinta
• Syphilis
• Nonvenereal Treponematoses: Yaws, Endemic Syphilis, and Pinta
• 19 Viral Diseases
• Herpesvirus Group
• Infectious Hepatitis
• Poxvirus Group
• Picornavirus Group
• Filovirus
• Paramyxovirus Group
• Parvovirus Group
• Arbovirus Group (Togaviridae)
• Papovavirus Group
• Retroviruses
• 20 Parasitic Infestations, Stings, and Bites
• Phylum Protozoa
• Phylum Cnidaria
• Phylum Platyhelminthes
• Phylum Annelida
• Phylum Nemathelminthes
• Phylum Arthropoda
• Phylum Chordata
• 21 Chronic Blistering Dermatoses
• Pemphigus Vulgaris
• Pemphigus Vegetans
• Pemphigus Foliaceus
• Endemic Pemphigus (Fogo Selvagem)
• Pemphigus Erythematosus (Senear-Usher Syndrome)
• Paraneoplastic Pemphigus
• IgA Pemphigus (Intraepidermal Neutrophilic IgA Dermatosis)
• Bullous Pemphigoid
• Pemphigoid Gestationis (Herpes Gestationis)
• Other Pregnancy-Related Dermatoses
• Cicatricial Pemphigoid (Mucous Membrane Pemphigoid)
• Epidermolysis Bullosa Acquisita
• Dermatitis Herpetiformis (Duhring Disease)
• Linear IgA Bullous Dermatosis
• Transient Acantholytic Dermatosis (Grover Disease)
• 22 Nutritional Diseases
• Vitamin A
• Hypervitaminosis A
• Vitamin D
• Vitamin K Deficiency
• Vitamin B1 Deficiency
• Vitamin B2 Deficiency
• Vitamin B6
• Vitamin B12 Deficiency
• Folic Acid Deficiency
• Vitamin C Deficiency (Scurvy)
• Niacin Deficiency (Pellagra)
• Disorders That Present With Acrodermatitis-Like Skin Changes
• Zinc Deficiency
• Essential Fatty Acid Deficiency
• Iron Deficiency
• Selenium Deficiency
• Protein-Energy Malnutrition
• Carotenemia and Lycopenemia
• 23 Diseases of Subcutaneous Fat
• Lobular Panniculitis
• Enzyme-Related Panniculitis
• Miscellaneous Forms of Panniculitis
• Lipodystrophy (Lipoatrophy)
• 24 Endocrine Diseases
• Acromegaly
• Cushing Syndrome
• Addison Disease
• Combined Pituitary Hormone Deficiency and Growth Hormone Deficiency
• Androgen-Dependent Syndromes
• Hypothyroidism
• Hyperthyroidism
• Hypoparathyroidism
• Hyperparathyroidism
• Acanthosis Nigricans
• 25 Abnormalities of Dermal Fibrous and Elastic Tissue
• Collagen
• Elastosis Perforans Serpiginosa
• Reactive Perforating Collagenosis
• Pseudoxanthoma Elasticum
• Perforating Calcific Elastosis
• Ehlers-Danlos Syndromes
• Marfan Syndrome
• Loeys Dietz Syndrome
• Homocystinuria
• Cutis Laxa (Generalized Elastolysis)
• Blepharochalasis
• Anetoderma (Macular Atrophy)
• Striae Distensae (Stretch Marks)
• Linear Focal Elastosis (Elastotic Striae)
• Acrodermatitis Chronica Atrophicans
• Osteogenesis Imperfecta
• 26 Errors in Metabolism
• Porphyrias
• Calcinosis Cutis
• Lipid Disturbances
• Skin Disorders in Diabetes Mellitus
• Other Metabolic Disorders
• 27 Genodermatoses and Congenital Anomalies
• X-linked, mosaic and related disroders with abnormal pigment
• Phakomatoses
• 28 Dermal and Subcutaneous Tumors
• Cutaneous Vascular Anomalies
• Vascular Tumors
• Syndromes Associated With Capillary Malformations
• Venous Malformation
• Arteriovenous Fistulas
• Other Lesions
• Lymphatic Malformations
• Kaposiform Lymphangiomatosis
• Hyperplasias
• Malignant Neoplasms
• Fibrous Tissue Abnormalities
• Abnormalities of Neural Tissue
• Abnormalities of Fat Tissue
• Abnormalities of Smooth Muscle
• Miscellaneous Tumors and Tumor-Associated Conditions
• 29 Epidermal Nevi, Neoplasms, and Cysts
• Epidermal Nevi
• Hyperkeratosis of the Nipple and Areola
• Clear Cell Acanthoma (Pale Cell Acanthoma)
• Waxy Keratoses of Childhood (Kerinokeratosis Papulosa)
• Multiple Minute Digitate Hyperkeratosis
• Acantholytic Acanthoma, Epidermolytic Acanthoma, Acantholytic Dyskeratotic Acanthoma
• Warty Dyskeratoma
• Seborrheic Keratosis
• Sign of Leser-Trélat
• Dermatosis Papulosa Nigra
• Stucco Keratosis
• Hyperkeratosis Lenticularis Perstans (Flegel Disease)
• Benign Lichenoid Keratoses (Lichen Planus–Like Keratosis)
• Arsenical Keratoses
• Nonmelanoma Skin Cancers and Their Precursors
• Actinic Keratosis (Solar Keratosis)
• Cutaneous Horn (Cornu Cutaneum)
• Keratoacanthoma
• Basal Cell Carcinoma
• Nevoid Basal Cell Carcinoma Syndrome (Gorlin Syndrome)
• Squamous Cell Carcinoma
• Verrucous Carcinoma (Carcinoma Cuniculatum)
• Bowen Disease (Squamous Cell Carcinoma in situ)
• Erythroplasia of Queyrat
• Balanitis Plasmacellularis (Zoon Balanitis)
• Pseudoepitheliomatous Keratotic and Micaceous Balanitis
• Paget Disease of the Breast
• Extramammary Paget Disease
• Clear Cell Papulosis
• Merkel Cell Carcinoma (Trabecular Carcinoma)
• Sebaceous Nevi and Tumors
• Sweat Gland Tumors
• Hair Follicle Nevi and Tumors
• Epithelial Cysts and Sinuses
• Congenital Preauricular Fistula
• 30 Melanocytic Nevi and Neoplasms
• Epidermal Melanocytic Lesions
• Becker Nevus
• Melanoacanthoma
• Benign Melanocytic Nevi
• Melanoma (Malignant Melanoma)
• Dermal Melanocytic Lesions
• 31 Macrophage/Monocyte Disorders
• Palisaded Granulomatous Dermatoses
• Necrobiotic Xanthogranuloma
• Sarcoidosis
• Histiocytoses
• Treatment and Prognosis.
• 32 Cutaneous Lymphoid Hyperplasia, Cutaneous T-Cell Lymphoma, Other Malignant Lymphomas, and Allied Diseases
• Cutaneous Lymphoid Hyperplasia (Lymphocytoma Cutis, Lymphadenosis Benigna Cutis, Pseudolymphoma)
• Cutaneous Lymphomas
• Angioimmunoblastic T-Cell Lymphoma and Angioimmunoblastic Lymphadenopathy With Dysproteinemia
• Cutaneous B-Cell Lymphoma
• Hodgkin Disease
• Malignant Histiocytosis (Histiocytic Medullary Reticulosis)
• Leukemia Cutis
• Cutaneous Myelofibrosis
• Hypereosinophilic Syndrome
• Sinus Histiocytosis With Massive Lymphadenopathy (Rosai-Dorfman Disease)
• Polycythemia Vera (Erythremia)
• 33 Diseases of the Skin Appendages
• Diseases of the Hair
• Cicatricial Alopecia
• Lymphoid-Mediated Disorders
• Neutrophil-Mediated Disorders
• Other Forms of Permanent Alopecia
• Atrichia With Papular Lesions
• Hair Color
• Hair Structure Defects
• Hypertrichosis
• Hirsutism
• Trichomycosis Axillaris
• Associated Hair Follicle Diseases
• Disorders of the Sweat Glands
• Diseases of the Nails
• Nail Discolorations
• 34 Disorders of the Mucous Membranes
• Cheilitis
• Oral and Cutaneous Crohn Disease
• Pyostomatitis Vegetans
• Cheilitis Granulomatosa
• Melkersson-Rosenthal Syndrome
• Fordyce Disease (Fordyce Spots)
• Stomatitis Nicotina
• Torus Palatinus
• Fissured Tongue
• Geographic Tongue
• Black Hairy Tongue
• Smooth Tongue
• Eruptive Lingual Papillitis
• Median Rhomboid Glossitis
• Eosinophilic Ulcer of the Oral Mucosa
• Caviar Tongue
• Cutaneous Sinus of Dental Origin (Dental Sinus)
• Neoplasms
• Trumpeter’s Wart
• Epulis
• Granuloma Fissuratum
• Angina Bullosa Hemorrhagica
• Mucocele
• Acute Necrotizing Ulcerative Gingivostomatitis (Trench Mouth, Vincent Disease)
• Acatalasemia
• Cyclic Neutropenia
• Recurrent Intraoral Herpes Simplex Infection
• Recurrent Aphthous Stomatitis (Canker Sores, Aphthosis)
• Major Aphthous Ulcer
• Behçet Syndrome (Oculo-Oral-Genital Syndrome)
• 35 Cutaneous Vascular Diseases
• Raynaud Phenomenon and Raynaud Disease
• Erythromelalgia
• Livedo Reticularis, Livedo Racemosa
• Livedoid Vasculopathy
• Calciphylaxis
• Marshall-White Syndrome and Bier Spots
• Purpura
• Thrombocytopenic Purpura
• Thrombotic Microangiopathy
• Nonthrombocytopenic Purpura (Dysproteinemic Purpura)
• Purpura Secondary to Clotting Disorders
• Drug-Induced, Food-Induced, and Recreational Activity–Associated Purpura
• Purpuric Agave Dermatitis
• Golfer’s and Exercise-Related “Vasculitis”
• Purpura Fulminans
• Disseminated Intravascular Coagulation
• Congenital Fibrinogen Disorders
• Blueberry Muffin Baby
• Miscellaneous Purpuric Manifestations
• Pigmentary Purpuric Eruptions (Progressive Pigmentary Dermatosis, Progressive Pigmenting Purpura, Purpura Pigmentosa Chronica)
• Vasculitis
• Small-Vessel Vasculitis
• Polyarteritis Nodosa
• ANCA-Positive Vasculitides
• Cocaine-Associated Vasculitis and Levamisole-Induced Vasculopathy/Vasculitis
• Giant Cell Arteritis/Temporal Arteritis
• Malignant Atrophic Papulosis
• Thromboangiitis Obliterans (Buerger Disease)
• Arteriosclerosis Obliterans
• Diffuse Dermal Angiomatosis
• Mucocutaneous Lymph Node Syndrome (Kawasaki Disease)
• Telangiectasia
• Hereditary Hemorrhagic Telangiectasia (Osler Disease)
• Leg Ulcers
• Venous Diseases of the Extremities
• Arterial Insufficiency (Ischemic) Ulcer
• Neuropathic Ulcers
• Lymphedema
• Types
• Evaluation
• Treatment
• 36 Disturbances of Pigmentation
• Pigmentary Demarcation Lines
• Abnormal Pigmentation
• Melasma (Chloasma)
• Reticulate Pigment Disorders of the Skin
• Dermatopathia Pigmentosa Reticularis
• Transient Neonatal Pustular Melanosis
• Peutz-Jeghers Syndrome
• Metallic Discolorations
• Idiopathic Guttate Hypomelanosis (Leukopathia Symmetrica Progressiva)
• Vitiligo
• Chemical Leukoderma (Occupational Vitiligo)
• Vogt-Koyanagi-Harada Syndrome
• Alezzandrini Syndrome
• Leukoderma
• Congenital Disorders of Hypopigmentation
• Oculocutaneous Albinism
• 37 Dermatologic Surgery
• Preparation for Surgery
• Biopsies
• Cryosurgery
• Curettage
• Electrosurgery
• Excisional Technique
• Skin Flaps and Grafts
• Mohs Micrographic Surgery
• Photodynamic Therapy
• Radiation Therapy for Skin Cancer
• 38 Cutaneous Laser Surgery
• Laser Principles
• Laser Treatment of Vascular Lesions
• Laser Treatment for Pigmented Lesions
• Laser Hair Removal
• Ablative Laser Resurfacing
• 39 Cosmetic Dermatology
• Soft Tissue Augmentation
• Botulinum Toxin
• Varicose and Telangiectatic Veins
• Fat Removal
• Chemical Peels
• Index