Hayes’ Principles and Methods of Toxicology, 2-Volume Set

Description:

Hayes’ Principles and Methods of Toxicology has long been established as a reliable and informative reference for the concepts, methodologies, and assessments integral to toxicology. The new edition contains updated and new chapters with the addition of new authors while maintaining the same high standards that have made this book a benchmark resource in the field.

Key Features:

• The comprehensive yet concise coverage of various aspects of fundamental and applied toxicology makes this book a valuable resource for educators, students, and professionals.
• Questions provided at the end of each chapter allow readers to test their knowledge and understanding of the material covered.
• All chapters have been updated and over 60 new authors have been added to reflect the dynamic nature of toxicological sciences
• New topics in this edition include Safety Assessment of Cosmetics and Personal Care Products, The Importance of the Dose/Rate Response, Novel Approaches and Alternative Models, Epigenetic Toxicology, and an Expanded Glossary.

The volume is divided into 4 major sections, addressing fundamental principles of toxicology (Section I. “Principles of Toxicology”), major classes of established chemical hazards (Section II. “Agents”), current methods used for the assessment of various endpoints indicative of chemical toxicity (Section III. “Methods”), as well as toxicology of specific target systems and organs (Section IV. “Organ- and System-Specific Toxicology”).

This volume will be a valuable tool for the audience that wishes to broaden their understanding of hazards and mechanisms of toxicity and to stay on top of the emerging methods and concepts of the rapidly advancing field of toxicology and risk assessment.

Preface

This is the seventh edition of Hayes’ Principles and Methods of Toxicology. It has been revised and updated while maintaining the high standards necessary to serve as a reference to the concepts, principles, methodologies, and assessments integral to toxicology. As was the case with the first six editions, chapters were revised and new chapters have been added to address advances and developments in the field of toxicology. These updates deal with the importance of hormesis, medical devices, biotechnology products, cosmetics and personal care products, new alternative methodologies, epigenetic toxicology, and the microbiome. More than 60 new authors have been added, and the glossary has been expanded. Every effort has been made to maintain this book as a tome useful to both graduate students beginning their educational journey as well as the more seasoned toxicologist.

The seventh edition welcomes a new co-editor, Tetyana Kobets, MD, MSPH, Assistant Dean for Ph.D. Programs, Assistant Professor of Pathology, Microbiology and Immunology at New York Medical College, Valhalla, NY. She brings not just new concepts and approaches to our science but also unyielding energy and enthusiasm to the book.

In many ways, toxicology remains a paradox. The words of Paracelsus, the 16th-century German-Swiss physician and alchemist, continue to remind us that the line between light and dark, good and evil, and poison and medicine is but a fine one that we as toxicologists have been given the awesome responsibility to divine, “Alle Ding’ sind Gift, und nichts ohn’

Gift; allein die Dosis macht, daß ein Ding kein Gift ist.” The first chapter reminds us of the evolution of toxicology, as it has matured over the centuries from its genesis as a science focused on the discovery and use of poison as an expedient tool to murder to the advances that have resulted in the use of toxicants to benefit mankind as medicines. Toxicology is much more than the science of poisons. Practitioners of toxicology need to understand the hazard and the underlying mechanisms of toxicity, as well as the principles of extrapolating experimentally derived hazard information to the assessment of risk under the conditions of exposure in the species of primary interest (humans). The vastness of the field of toxicology and the rapid accumulation of data preclude any individual from absorbing and retaining more than a fraction of the methods, techniques, and information being developed on a daily basis. However, an understanding of the principles underlying these methods is not only manageable but also essential for the practicing toxicologist, and it is to this end that this book was conceived and continues in this edition. And thus, we hope to provide in this edition, as before, an experience that continues to educate, elucidate, nurture the inquisitive, and foster the motivation to learn. We begin with four basic principles of toxicology—dose matters, people differ, everything transforms, and timing is crucial. The relevance of these principles is waiting to be discovered, challenged, and applied in the following chapters.