Tietz Textbook of Laboratory Medicine, 7th Edition

Description:

Use THE definitive reference for laboratory medicine and clinical pathology! Tietz Textbook of Laboratory Medicine, 7th Edition provides the guidance necessary to select, perform, and evaluate the results of new and established laboratory tests. Comprehensive coverage includes the latest advances in topics such as clinical chemistry, genetic metabolic disorders, molecular diagnostics, hematology and coagulation, clinical microbiology, transfusion medicine, and clinical immunology. From a team of expert contributors led by Nader Rifai, this reference includes access to wide-ranging online resources on Expert Consult ― featuring the comprehensive product with fully searchable text, regular content updates, animations, podcasts, over 1300 clinical case studies, lecture series, and more.

• Authoritative, current content helps you perform tests in a cost-effective, timely, and efficient manner; provides expertise in managing clinical laboratory needs; and shows how to be responsive to an ever-changing environment.
• Current guidelines help you select, perform, and evaluate the results of new and established laboratory tests.
• Expert, internationally recognized chapter authors present guidelines representing different practices and points of view.
• Analytical criteria focus on the medical usefulness of laboratory procedures.
• Use of standard and international units of measure makes this text appropriate for any user, anywhere in the world.
• Expert Consult provides the entire text as a fully searchable eBook, and includes regular content updates, animations, podcasts, more than 1300 clinical case studies, over 2500 multiple-choice questions, a lecture series, and more.

• NEW! 19 additional chapters highlight various specialties throughout laboratory medicine.
• NEW! Updated, peer-reviewed content provides the most current information possible.
• NEW! The largest-ever compilation of clinical cases in laboratory medicine is included on Expert Consult.
• NEW! Over 100 adaptive learning courses on Expert Consult offer the opportunityfor personalized education.

See more medical ebooks at here:

Moore’s Clinically Oriented Anatomy 7th edition 2014

Artificial Intelligence in the Clinical Laboratory

Human Anatomy: Color Atlas and Textbook 6th Edition

A Textbook of Cardiovascular Medicine 11th Edition 2018 (2-Volume Set)

Evidence-Based Emergency Care: Diagnostic Testing and Clinical Decision Rules

Healthcare Design Basics

Preface

We are pleased to introduce the seventh edition of the Tietz Textbook, now entitled, Tietz Textbook of Laboratory Medicine. We have expanded the scope of chapters from the sixth edition to include various specialties throughout laboratory medicine. In addition, we further refined and enriched the Platform, a concept we introduced in the sixth edition, of which the Textbook is only a component.

Although the textbook is available in print for selected chapters, the comprehensive product is only available electronically on the Platform. The chapters in the print version of the textbook are meant to give readers a taste of the entire product and to demonstrate its broad scope. Using Elsevier’s Expert Consult electronic system, the Platform encompasses:

• A textbook covering all major disciplines of laboratory medicine including clinical chemistry, genetic metabolic disorders, molecular diagnostics, hematology and coagulation, clinical microbiology, transfusion medicine, and clinical immunology. Thirty additional chapters are devoted to analytical techniques and basic practices in laboratory medicine, and an extensive compilation of reference intervals is included. Compared to the previous edition, the number of chapters has increased from 81 to 100

• Electronic search capability and a built-in medical dictionary

• Curriculum-based courses utilizing the concept of adaptive learning provide the users with a personalized education experience (https://rhapsode.com/laboratorymedicine/). Over 100 courses, which span across all disciplines of laboratory medicine, encompass more than 15,000 learning objectives and are authored by world-renowned scientists and physicians; almost 50% of these courses were prepared or reviewed by authors participating in this textbook. Courses are linked to the appropriate chapters

• Multimedia and Educational Resources for an enhanced learning experience that include:

1. The largest compilation ever assembled of clinical cases in laboratory medicine
2. Animation films to explain complex mechanisms and concepts
3. Podcasts
4. Lecture series
5. Biochemical calculations
6. Collections of morphologic images and electrophoretic patterns
7. Banks of multiple-choice and short-answer questions
8. Important documents, monographs, and guidebooks

The above-described features are linked to the appropriate chapters for the convenience of the reader. These resources were either previously created by prominent laboratory medicine professionals (e.g., Allan Deacon, Michael J. Murphy, Rajeev Srivastava, Allan Gaw, Bobbi Pritt, Ellen F. Foxman, Julie E. Buring, Pamela Rist, Roy Peake, Morayma Reyes Gil, Matthew Diggle, Vera Paulson, Christina Lockwood, Gifford Batstone, Gary Weaving, Kate Shipman, Tamsyn Cromwell, and John Coakley), prestigious journals (e.g., Journal of Clinical Microbiology, Clinical Chemistry, Transfusion, American Journal of Hematology and Blood) and leading international scientific societies (e.g., the Association for Clinical Biochemistry and Laboratory Medicine-United Kingdom, Association of Clinical Biochemists-Ireland, Royal Society of Chemistry-London, Imperial College-London, Association of Molecular Pathology, and American Association for Clinical Chemistry), or produced de novo by accomplished scientists and physicians using materials from their own institutions (e.g., Mayo Medical Laboratories, ARUP, HudsonAlpha Institute for Biotechnology, Hôpital Universitaire La Pitié Salpêtrière-Paris, Pathology Queensland-Australia, and Boston Children’s Hospital).

• A living product, where materials are periodically added and information updated as necessary

Our hope for this Platform is to serve as a resource center where important materials in laboratory medicine are deposited for use by and for the benefit of the community at large. Therefore, we encourage those who have similar materials and wish to have them considered for the Platform to contact one of the editors. The Platform can only be enhanced by further efforts.

Unlike most other textbooks, all chapters in this edition were reviewed by three individuals: a reviewer, an associate editor, and a senior editor. We believe that these efforts have led to a better product. In addition, we made a concerted effort to create an International rather than an American Platform; about one third of the authors, reviewers, and editors reside outside the United States. We have strongly encouraged authors to include European, Australasian, and other international guidelines in addition to the American ones in order to present different practices and points of view. Furthermore, all measurements are presented both in traditional and SI units.

We aimed to harmonize the presentation of information among chapters while retaining the personality and unique style of each author, hoping for a readable, educational text with enough variety to amuse and occasionally delight.

This ambitious project has been a true group effort and represents the collective intellect, knowledge, and experience of almost 230 leaders in laboratory medicine from 18 countries.

We are in debt not only to the authors, reviewers, and editors of the chapters but also to the contributors of the Multimedia and Educational Resources materials and the Adaptive Learning Courses that greatly enriched the Platform. We are grateful to Elsevier, and particularly to Heather Bays-Petrovic, Maria Broeker, and Rachel McMullen and their team for supporting us throughout this project to realize our vision.

We sincerely hope that this product will be a valuable educational and reference resource for the laboratory medicine community worldwide.

Nader Rifai Rossa W.K. Chiu Ian Young
Carey-Ann D. Burnham Carl T. Wittwe

Table of contents :

Cover
Tietz Textbook of Laboratory Medicine
Copyright
Dedication
Preface
Textbook Associate Editors
Textbook Reviewers
Textbook Contributors
Table of Contents
Multimedia & Educational Resources Associate Editors
Multimedia & Educational Resources Contributors
Multimedia & Educational Resources Contents
Adaptive Learning Editors
Adaptive Learning Courses Contents
Section I. Basics of Laboratory Medicine
1. Laboratory medicine
2. Statistical methodologies in laboratory medicine
3. Governance, risk, and quality management in the medical laboratory
4. Specimen collection and processing
5. Preanalytical variation and pre-examination processes
6. Quality control of the analytical examination process
7. Standardization and harmonization of analytical examination results
8. Biological variation and analytical performance specifications
9. Establishment and use of reference intervals
10. Evidence-based laboratory medicine
11. Biobanking
12. Laboratory support of pharmaceutical, in vitro diagnostics, and epidemiologic studies
13. Machine learning and big data in laboratory medicine
14. Laboratory stewardship and test utilization
15. Principles of basic techniques and laboratory safety
Section II. Analytical Techniques
16. Optical techniques
17. Electrochemistry and chemical sensors
18. Electrophoresis
19. Chromatography
20. Mass spectrometry
21. Sample preparation for mass spectrometry
22. MALDI-TOF mass spectrometry applications in infectious diseases
23. Development and validation of small molecule analytes by liquid chromatography-tandem mass spectrometry
24. Proteomics
25. Enzyme and rate analysis
26. Immunochemical techniques
27. Microfabrication and microfluidics and their application in clinical diagnostics
28. Cytometry
29. Automation in the clinical laboratory
30. Point-of-care testing
Section III. Clinical Chemistry-Analytes
31. Amino acids, peptides, and proteins
32. Serum enzymes
33. Tumor markers
34. Kidney function tests
35. Carbohydrates
36. Lipids and lipoproteins
37. Electrolytes and blood gases
38. Hormones
39. Vitamins and trace elements
40. Iron metabolism
41. Porphyrins and the porphyrias
42. Therapeutic drugs and their management
43. Clinical toxicology
44. Toxic elements
45. Body fluids
Section IV. Clinical Chemistry-Pathophysiology
46. Nutrition: Laboratory and clinical aspects
47. Diabetes mellitus
48. Cardiac function
49. Kidney disease
50. Disorders of water, electrolytes, and acid-base metabolism
51. Liver disease
52. Gastric, intestinal, and pancreatic function
53. Monoamine-producing tumors
54. Bone and mineral metabolism
55. Pituitary function and pathophysiology
56. Adrenal cortex
57. Thyroid disorders
58. Reproductive endocrinology and related disorders
59. Pregnancy and its disorders
Section V. Genetic Metabolic Disorders
60. Newborn screening and inborn errors of metabolism
61. Inborn errors of metabolism: Disorders of complex molecules
Section VI. Molecular Diagnostics
62. Principles of molecular biology
63. Nucleic acid isolation
64. Nucleic acid techniques
65. Genomes, variants, and massively parallel methods
66. Clinical genome sequencing
67. Molecular microbiology
68. Genetics
69. Solid tumors
70. Hematopathology
71. Circulating tumor cells and circulating nucleic acids in oncology
72. Circulating nucleic acids for prenatal diagnostics
73. Pharmacogenetics
Section VII. Hematology and Coagulation
74. Automated hematology
75. Leukocyte morphology in blood and bone marrow
76. Red blood cell morphology and indices: The clinical chemistry interface
77. Hemoglobin and hemoglobinopathies
78. Enzymes of the red blood cell
79. Physiology of hemostasis
80. Platelets and von Willebrand factor
81. Coagulation, anticoagulation, and fibrinolysis
Section VIII. Microbiology
82. Introduction to infectious diseases
83. The role of the clinical laboratory in infection prevention and antimicrobial stewardship
84. Bacteriology
85. Antimicrobial susceptibility testing
86. Mycobacteriology
87. Mycology
88. Parasitology
89. Virology
Section IX. Transfusion Medicine
90. Blood group systems and pretransfusion testing
91. Blood components, product modifications, and blood donor screening
92. Indications for transfusion: RBCs, platelets, plasma, and cryoprecipitate
93. Transfusion reactions and adverse events associated with transfusion
Section X. Clinical Immunology
94. Systemic autoimmune disease
95. Transplant, solid organ
96. Hematopoietic cell transplantation
97. Transplant compatibility testing
98. Monoclonal antibody therapeutics and immunogenicity
99. Allergy testing
100. Primary immunodeficiencies and secondary immunodeficiencies
Appendix A: Reference information for the clinical laboratory
Appendix B: Answers to multiple choice questions
Index