The aim of this meta-analysis was to determine the relationship between microRNA polymorphisms and the risk of childhood acute lymphoblastic leukemia comprehensively. PubMed, EMBASE, Scopus, Web of Science, the Cochrane Library, Global Index Medicus, Clinicaltrials.gov, ProQuest, and Open Grey databases were used to find relevant papers. Using the STATA 16.0 and CMA 3.0 software, the significance of relationships between microRNA polymorphisms and childhood acute lymphoblastic leukemia risk was evaluated using odds ratios (ORs) and 95 % confidence intervals (95 % CIs) for five genetic models. The results of the meta-analysis showed that there was no significant association between the polymorphism of miR-146a rs2910164 and childhood acute lymphoblastic leukemia risk in different genetic models. Also, in the sensitivity analysis, removing Xue’s study from the analysis indicated that both the homozygote and recessive models are significantly affected. Additionally, there was a statistically significant relationship between the polymorphisms of pri-miR-34b/c rs4938723 (in the homozygote and recessive models) and miR-612 rs12803915 (in the allele and dominant models) and childhood acute lymphoblastic leukemia risk. These findings suggest that the rs4938723 and rs12803915 polymorphisms may have a role in the development of childhood acute lymphoblastic leukemia.
- • There was no significant association between the polymorphism of miR-146a rs2910164 and childhood ALL risk in all models.
- • There was a statistically significant relationship between the polymorphisms of pri-miR-34b/c rs4938723 and childhood ALL risk.
- • There was a statistically significant relationship between the polymorphisms of miR-612 rs12803915 and childhood ALL risk.
Acute lymphoblastic leukemia (ALL), a malignant disorder of immature lymphoid progenitors, is the most common pediatric cancer in developed societies . This disease causes approximately one third of pediatric malignancies. It is more common in boys, and the peak age of onset is 2–5 years old . ALL is a multifactorial disease that has no recognized etiology yet . Infection, environmental and geographical variables, and genetic susceptibility are factors that influence the occurrence of ALL in different communities . A microRNA (miRNA) is a small non-coding regulatory RNA molecule of approximately 22 nucleotides that binds to the 3′-UTR of target mRNAs to silence their expression after transcription . In addition, miRNAs have a key function in biological processes such as proliferation, apoptosis, and development . SNPs (single nucleotide polymorphisms) are common genetic variations in DNA sequences that have the potential to be used as biomarkers for cancer risk prediction . Since some SNPs are located in miRNA-producing genes, miRNA processing machinery, or miRNA target genes, they might influence the ultimate level and function of miRNAs . Several case-control studies have shown that SNPs in miRNAs, including rs2910164 (G > C) in miR-146a, rs11614913 (T > C) in miR-196a2, rs4938723 (T > C) in pri-miR-34b/c, rs12803915 (G > A) in miR-612, and rs3746444 (A > G) in miR-499, may be associated with childhood ALL risk, but the research conclusions are not the same . In this study, the meta-analysis method was used to systematically evaluate the association between the polymorphism of the afore-mentioned miRNAs and the susceptibility of childhood ALL, in order to provide evidence-based medicine.