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Allergy Essentials, 2nd Edition

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Title: Allergy Essentials
Author: Robyn E. O’Hehir, Stephen T Holgate, Gurjit K. Khurana Hershey, Aziz Sheikh
Publisher: Elsevier
Publication: 2021
Edition: 2nd Edition
Language: English
Pages: 334
Ebook: PDF
File size: 20.9 MB
ISBN Number: 9780323809139
CBID: CBM107

Categories: eBooks, Medical eBooks Tags: 2nd Edition, Allergy Essentials

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Perfect for clinicians in both primary and secondary care settings, Allergy Essentials, 2nd Edition, covers the information you need most in your daily practice, with a strong emphasis on disease diagnosis and management. In one concise, convenient volume, it covers all common allergies in children and adults, offering authoritative content from the world’s leading allergy experts in conjunction with primary care/family practitioners for a practical, balanced approach. You’ll find up-to-date information on everything from basic immunology and physiology to new medications, new therapies, and individualized treatment options, allowing you to confidently integrate these changes into your practice.

Cover image
Title page
Table of Contents
Any screen, Any time, Anywhere
Copyright
Preface
Contributors
1. Introduction to Mechanisms of Allergic Diseases
Abstract
Chapter Outline
Summary of Important Concepts
Introduction
Innate Immunity
Adaptive Immunity
Immunoglobulin Structure and Function
Immunoglobulins and Human Disease
Immune Tolerance
Cytokines and Chemokines in Allergic Inflammation
Biology of Immune Cells
Contribution of Structural Cells to Allergic Inflammation
Cytokine Networks in Allergic Inflammation
Microbiome and Immune System
Food Allergy as a Model for Allergic Diseases
Resolution of Allergic Inflammation and Major Pathways
References
2. Precision Medicine
Abstract
Chapter Outline
Precision Medicine: A Brief History and Definition
Evidence-Based Versus Precision Medicine
Components of Precision Medicine in Allergic Disorders
Precision Medicine in the Management of Allergic Disorders
Biologics and Precision Medicine
Challenges in Precision Medicine
Summary
References
3. Epidemiology of Allergic Diseases
Abstract
Chapter Outline
Summary of Important Concepts
Introduction
Epidemiological Definitions of Allergic Diseases: Part of the Challenge
Estimates of Worldwide Prevalence of Asthma, Rhinitis, Ad, and Food Allergy
Trends in Prevalence Over Time
Risk Factors for Asthma and Allergic Diseases
Concluding Remarks
References
4. Indoor and Outdoor Allergens and Pollutants
Abstract
Chapter Outline
Summary of Important Concepts
Introduction
Allergens and Allergenicity
Indoor and Outdoor Allergen Sources
Aerobiology of Indoor and Outdoor Allergen Sources
Allergen Monitoring—Whole Spores, Pollens, and Mites
Measuring Specific Allergens
The Chemical Nature of Allergens
Allergen Nomenclature and Allergen Databases
Outdoor Allergens
Indoor Allergens
Allergens and Allergenicity
Environmental Modifiers of Allergic Sensitization and Disease
Environmental Air Pollution, Allergic Sensitization, and Disease
Types of Pollutant and Their Effects on Allergens, Allergic Sensitization, and Asthma
Air Pollution, Climate Change, and Allergens
Conclusions
Acknowledgments
References
5. Principles of Allergy Diagnosis
Abstract
Chapter Outline
Introduction
Use of IgE Sensitization Tests in Epidemiology
Pathogenesis and Etiology
Clinical Features
Patient Evaluation
Referral
Conclusions
References
6. Allergen-Specific Immunotherapy
Abstract
Chapter Outline
Summary of Important Concepts
Introduction
Historical Perspective
Indications for Specific Allergen Immunotherapy
Clinical Efficacy with Specific Allergens
Specificity of Allergen Immunotherapy
Evidence of Disease Modification
Pharmacoeconomics of Sit
Immunologic Response to Inhalant Sit
Overview of the Immune Response to Immunotherapy
Indications for Sit
Sublingual Immunotherapy
Modified Allergen Extracts and Adjuvants (Box 6.6)
The Future of Slit
Conclusions
References
Suggested Reading
7. Asthma
Abstract
Chapter Outline
Summary of Important Concepts
Introduction and Overview
Historical Perspective
Epidemiology
Pathogenesis and Etiology
Clinical Features and Phenotypes of Asthma
Evaluation and Diagnosis
Asthma Management
Acute Asthma and Referral for Hospital Care
Conclusions
Asthma Diagnosis and Monitoring
References
8. Allergic Rhinitis and Conjunctivitis
Abstract
Chapter Outline
Summary of Important Concepts
Introduction
Historic Perspective
Epidemiology
Pathogenesis and Etiology
Treatment
Indications for Referral
Concluding Remarks
References
9. Drug Allergy
Abstract
Chapter Outline
Summary of Important Concepts
Introduction
Historical Perspective
Epidemiology
Pathogenesis and Etiology
Clinical Features (Phenotypes)
Urticaria And Angioedema (Immediate Type)
Maculopapular Exanthem (Delayed Type)
Fixed Drug Eruptions (Delayed Type)
Exfoliative Dermatitis (Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis) (Delayed Type)
Systemic Drug Reactions—Severe Drug Hypersensitivity Syndromes (DHS/DRESS) (Delayed Type)
Isolated Drug-Induced Organ Damage (Delayed Type)
Pediatric Aspects in Drug Allergy
Patient Evaluation, Diagnosis, and Differential Diagnosis
Drug Classes of Special Interest
Treatment
Referral
Conclusions
References
10. Urticaria
Abstract
Chapter Outline
Summary of Important Concepts
Introduction and Historical Perspective
Definitions and Classifications
Epidemiology
Natural History and Prognosis
Disease Associations
Pathogenesis and Etiology
Diagnostic Approach
Treatment of Urticaria
References
11. Atopic Dermatitis and Allergic Contact Dermatitis
Abstract
Chapter Outline
Atopic Dermatitis
Introduction
Historical Perspective
Epidemiology
Pathogenesis And Etiology
Clinical Features (Phenotype)
Complicating Features
Patient Evaluation, Diagnosis, and Differential Diagnosis
Treatment
Recalcitrant Disease
Experimental and Unproven Therapies
Conclusions Regarding Ad
Allergic Contact Dermatitis
Introduction
Epidemiology
Pathogenesis and Etiology
Clinical Features
Patient Evaluation, Diagnosis, and Differential Diagnosis
Treatment
Referral
Conclusions Regarding ACD
What’s New in ACD
References
12. Food Allergy and Gastrointestinal Syndromes
Abstract
Chapter Outline
Summary of Important Concepts
Introduction
Epidemiology
Clinical Features
Patient Evaluation, Diagnosis, and Differential Diagnosis
Food Allergy Treatment
Emergency Management
Conclusions
References
13. Anaphylaxis
Abstract
Chapter Outline
Summary of Important Concepts
Introduction
Historical Perspective
Epidemiology
Pathophysiology
Clinical Features (Phenotypes)
Patient Evaluation, Diagnosis, and Differential Diagnosis
Treatment
Ongoing Management and Referral
Conclusions
References
14. Occupational Allergy
Abstract
Chapter Outline
Summary of Important Concepts
Introduction and Definitions
Epidemiology
Pathogenesis and Etiology
Clinical Features
Patient Evaluation, Diagnosis, and Differential Diagnosis
Outcomes and Treatment
Prevention
SocioEconomic Impact and Medicolegal Aspects
Work-Related Anaphylaxis
Conclusions
References
15. Insect Allergy
Abstract
Chapter Outline
Summary of Important Concepts
Stinging Insect Allergy
Historical Perspective
Epidemiology
Etiology
Insect Venoms
Clinical Features and Classification of Reactions
Patient Evaluation and Diagnosis
Treatment of Acute Reactions
Prevention of Acute Reactions
Predictors of Risk for Sting Anaphylaxis
Venom Immunotherapy
Biting Insect Allergy
Inhalant Insect Allergy
Conclusions
References
A Appendix. Internet Resources
Index

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